Many common medications can negatively impact memory and cognitive function, especially with long-term use. It’s important to understand how certain drugs may contribute to mental decline and to speak with a healthcare provider about safer alternatives.

Proton pump inhibitors like omeprazole, used for heartburn, may increase the risk of cognitive issues when taken long-term. Similarly, anticholinergic drugs—used for Parkinson’s, bladder issues, and more—block acetylcholine, a key neurotransmitter for memory. One study found regular users had a 54% higher risk of dementia.

Corticosteroids, prescribed for inflammation and autoimmune diseases, can cause anxiety, confusion, and depression with prolonged use. A British study linked them to an elevated risk of dementia.

Benzodiazepines, such as alprazolam and diazepam, are effective for anxiety and insomnia but can lead to lasting memory problems and dependency. Around 40% of users report cognitive issues.

Amphetamines, used for ADHD, boost focus short-term but may cause long-term memory deficits and addiction risks.

First-generation antihistamines, like diphenhydramine, also carry anticholinergic effects and are linked to dementia. Safer options like cetirizine are recommended.

Tricyclic antidepressants can impair memory too.

If you’re concerned, consult your doctor and consider non-drug alternatives like cognitive behavioral therapy. Protecting your brain starts with informed choices.